Pharmacokinetics of N-(4-bromobenzyl)-N-(4-bromobenzyloxy)urea in rats
- Author:
Wei TONG
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
HPLC;
N-(4-bromobenzyl)-N-(4-bromobenzyloxy)urea;
Pharmacokinetics;
Rat
- From:
Chinese Pharmaceutical Journal
2012;47(21):1746-1749
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To characterize the pharmacokinetics of N(4-bromobenzyl) -N-(4-bromobenzyloxy) urea (BBU) in rats after oral administration, thus to provide reference for its development. METHODS: A single dose of 600 mg · kg-1 of BBU was orally administered to rats. The concentration of free BBU in rat plasma was determined by HPLC. RESULTS: The AUC0-t and AUC0-∞ were 110.55 and 122.79 mg · L · h-1, t1/2z and tmax were 3.71 and 3.67 h, ρmax was 17.49 mg · L-1, CLz/F and Vz/F were 4.97 L · h-1 · kg-1 and 26.10 L · kg-1, and MRT0-∞ was 6.71 h for free BBU. CONCLUSION: The fitting goodness is between one-compartment model and two-compartment model. Both models can be chosen, but two-compartment model is better.
