Association of PROC genetic polymorphism with warfarin dose
- Author:
Hai-Yan ZHANG
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Polymorphism;
PROC;
Warfarin
- From:
Chinese Pharmaceutical Journal
2012;47(21):1741-1745
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the association of PROC rs5936 polymorphism with warfarin maintenance dose in the Han population in the south of Jiangsu province. METHODS: The single nucleotide polymorphism was detected by base-quenched probe technique and PCR-RFLP technique. VKORC1-1639G > A, CYP2C9 1075A > C and PROC rs5936 polymorphisms were analyzed in 188 patients after mechanical heart valve replacement. RESULTS: Among the 188 patients, the genotypic frequency of PROC rs5936 was T 54.78% and G 45.22%. The required warfarin doses for patients with different PROC rs5936 GG genotypes were (2.55 ± 0.81) mg · d-1 for GG, (2.65 ± 0.96) mg · d-1 for TG, and (2.64 ± 0.74) mg · d-1 for TT, respectively. PROCrs5936 genotype did not show association with warfarin dose (P > 0.05). The genotypes of VKORC1-1639G > A and CYP2C9 1075A > C had significant association with warfarin dose (P < 0.001), and accounted for respectively 30.2% and 7% variance of warfarin dose. CONCLUSION: VKORC1-1639G > A and CYP2C9 1075A > C genotypes have significant association with the dose of warfarin, yet, no impact was observed for PROC rs5936 in the Han population of the south of Jiangsu province.
