Protective effect of 3-acetyl-4-acetoxy-2-benzoxazolone against acute liver injury induced by carbon tetrachloride in mice

Author: Shun-Yu LU ¹
Author Information

1. Department of Pharmacology
Publication Type:Journal Article
Keywords: 3-acetyl-4-acetoxy-2-benzoxazolone; Acute liver injury; CCl4
From: Chinese Pharmaceutical Journal 2012;47(22):1813-1816
CountryChina
Language:Chinese
Abstract: OBJECTIVE: To study the protective effect of 3-acetyl- 4-acetoxy-2-benzoxazolone on liver injury induced by carbon tetrachloride (CCl4) in mice. METHODS: The serum activities of ALT and AST and the levels of MDA, SOD and GSH in liver tissue were measured in the model of acute liver injury induced by intraperitoneal injection 0.15% CCl4 and hepatic histological changes were observed by optical microscope. RESULTS: Compared with control group, the serum ALT, AST and the liver tissue MDA activities were significantly lowered, the levels of SOD and GSH in liver tissue were increased obviously. Histological results showed that 3-acetyl- 4-acetoxy-2-benzoxazolone could ameliorate histological damages induced by CCl4 in mice. CONCLUSION: 3-Acetyl-4-acetoxy-2-benzoxazolone exhibits protective effects on experimental hepatic injury.