Effect of polymorphism in VKORC1 and CYP2C9 on warfarin dosage in elderly patients
- Author:
Ya-Tong ZHANG
1
Author Information
1. Department of Pharmacy Beijing Hospital
- Publication Type:Journal Article
- Keywords:
CYP2C9;
Elderly patient;
Genetic polymorphism;
Individualization medication;
VKORC1;
Warfarin
- From:
Chinese Pharmaceutical Journal
2012;47(23):1930-1933
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the effect of genetic factors and non-genetic factors on warfarin dosage in patients older than 60 years. METHODS: Patients older than 60 years were included. Blood samples were collected and tested for VKORC1 and CYP2C9 genotypes. And the clinical data were collected. The effects of genetic factors and non-genetic factors on stable dosage of warfarin were statistically analyzed. RESULTS: VKORC1 and CYP2C9 genotypes had a significant effect on warfarin dosage. The four variables, ie, VKORC1: 1173C > T, body weight, aspartate aminotransferase (AST), and CYP2C9 * 3 could explain 23.2% of the stable warfarin dosage variation. CONCLUSION: Genetic factors have significant effect on warfarin dosage in elderly patients, so genetyping on VKORC1 and CYP2C9 can be applied to individualize warfarin dosage in elderly patients.
