Effect and mechanism of catechin on experimental atherosclerosis in quails
- Author:
Chun-Gang YU
1
Author Information
- Publication Type:Journal Article
- Keywords: Atherosclerosis; Catechin; Malondialdehyde; Quail; Superoxide dismutase
- From: Chinese Pharmaceutical Journal 2013;48(3):181-185
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the effect and mechanism of catechin on experimental atherosclerosis in quails. METHODS: Atherosclerosis model in quail was established by high fat diet. The serum and tissue lipid contents were detected with enzyme method. The atherosclerotic plaque lesion of aorta was observed by naked eyes and under light microscope. The serum superoxide dismutase (SOD) and malondiadehyde (MDA) in quail were observed with microcontent fast detecting method. RESULTS: After eight weeks continuous administration, the serum levels of triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) (P<0.05, P<0.01) were decreased in all catechin groups, the serum level of high density lipoprotein cholesterol (HDL-C) was increased in middle dose catechin group (P<0.05) compared with model group, while the serum levels of HDL-C in high and low dose catechin group showed trend of increase (P≤05). At the same time, TC and TG in the liver, myocardial and aortic wall and the degree of atherosclerotic lesion in aorta and fatty degeneration of liver in catechin groups were reduced (P<0.05, P<0.01), the level of the serum SOD was increased while MDA level was reduced (P<0.05, P<0.01). CONCLUSION: Catechin can prevent atherosclerotic lesion probably through decreasing blood lipid level and antioxidation.
