Preparation and in vivo evaluation of glycgrrhizin acid-sodium deoxycholate/phospholipid-mixed micelles
- Author:
Shi-Xiao JIN
1
Author Information
- Publication Type:Journal Article
- Keywords: Glycyrrhizin; In situ intestinal absorption; Pharmacokinetics; Sodium deoxycholate/phospholipid-mixed micelle
- From: Chinese Pharmaceutical Journal 2013;48(4):280-285
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To improve the oral bioavailability of glycyrrhizin by preparing glyeyrrhizin-sodium deoxycholate/phos-pholipid-mixed micelles (GL-SDC/PL-MMs). METHODS: GL-SDC/PL-MMs was prepared by a film dispersion method. In order toevaluate the property GL-SDC/PL-MMs comprehensively, physical and chemical properties determination, in situ intestinal absorption, and pharmacokinetics test were carried out. RESULTS: The average particle size of drug-loaded micelles prepared by film dispersion method was (82.99±7.5) nm and Zeta potential was (-32.23±1.05) mV. Compared with the control drug, glycyrrhizin loaded in SDC/PL-MMs significantly improved its in situ intestinal absorption. The oral bioavailability was markedly enhanced, indicated by the increase of ρmax to 77.26 μg · mL-1, which was 2.82 times of that of the control drug. CONCLUSION: SDC/PL-MMs is expected to be developed into a new drug delivery systems of GL.
