Preparation and stability of geniposide cream
- Author:
Min-Jie SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: Cream; Geniposide; Preparation technology; Stability
- From: Chinese Pharmaceutical Journal 2013;48(6):455-460
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To prepare an o/w type geniposide cream and to investigate its stability. METHODS: Appropriate base was selected by uniform design; suitable preservative and penetration enhancer were chosen according the characteristics of the cream. Franz diffusion cell was used to evaluate the transdermal characteristics in vitro; the stability and rheology of the cream were evaluated. RESULTS: The optimum matrix was composed of oil phase of volume faction 33%, emulsifying agent 6%, and preservative 0.3%. The content of geniposide was 0.5%. The emulsifying temperature was 80°C. The cream was uniform in color, homogeneous, exquisite and easy to spread; 12 h cumulative penetration amount was (212.73±22.76)μg · cm-2. The contents and pHs of three batches oi samples were in accordance with the quality standard after storage at 40°C, 25°C and 4°C for 3 months. CONCLUSION: Geniposide cream is very stable and has good transdermal characteristics in vitro, which is a new dosage form for transdermal drug deliveiy.
