Determination of residual organic solvents in 2-2-methyl-4-2-4-(trifluoromethyl) phenyl pyrimidin-4-yl methylsulfanyl phenoxy acetic acid by capillary gas chromatography
- Author:
Hui CHE
1
Author Information
- Publication Type:Journal Article
- Keywords: 2-[2-methyl-4-[[2-[4-(trifluoromethyl) phenyl] pyrimidin-4-yl] methylsulfanyl] phenoxy] acetic acid; GC; Residual solvent
- From: Chinese Pharmaceutical Journal 2013;48(7):562-564
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To establish a capillary GC method for the determination of residual solvents including ethanol, acetoni-trile, acetone, isopropanol, ethyl acetate, dioxane and THF in 2-[2-methyl-4-[[2-[4-(trifluoromethyl) phenyl] pyrimidin-4-yl] methylsulfanyl] phenoxy] acetic acid. METHODS: The residual organic solvents were separated on DB-1capillary column (30 m × 0.53 mm, 5.00 μm). FID was used as detector with a temperature of 250°C, and the inlet temperature was 160°C. The carrier gas was nitrogen, and the column temperature was programmed set. The contents of residual solvents were calculated by external standard method. RESULTS: The seven residual organic solvents were completely separated, the recovery rates and linear relationship were good, and three batches of samples all met the requirements. CONCLUSION: The method is simple, accurate, and reproducible, so it can be used for the detection of seven residual organic solvents in the raw.
