In situ absorption of self-microemulsifying drug delivery system of Diospyros kaki L. f. extract in rats' intestine
- Author:
Sheng-Miao CUI
1
Author Information
- Publication Type:Journal Article
- Keywords: Diospyros kaki L.f. extract; Intestinal absorption in situ; Self-microemulsifying drug delivery system
- From: Chinese Pharmaceutical Journal 2013;48(9):715-719
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the intestinal absorption behaviors of Diospyros kaki L.f. extract (PLE) in self-microemulsifying drug delivery system (SMEDDS). METHODS: The concentration of quercetin, kaempferol and phenol red in rat intestinal perfusion solution was determined by HPLC. Rat single-pass intestinal perfusion technique was employed to assay the effects of concentrations of PLE in perfusion solution, intestinal segments and different formulations on the drug percentage absorbed (P) and the absorption rate constant (Ka). RESULTS: No significant changes of Ka and P were observed in different PLE concentrations. The main absorption segments of SMEDDS in rat intestines were the duodenum and ileum. The values of Ka and P of SMEDDS were significantly higher than the PLE solution (P<0.05). CONCLUSION: The absorption mechanism of PLE conforms to passive diffusion. The PLE SMEDDS presented the high absorption rate than conventional solution in rat intestine, which illustrates the potential use of SMEDDS for the delivery o f PLE by the oral route.
