Synthesis of arachidic acid-cholic acid conjugate aramchol for treating disordered lipid metabolism
- Author:
Zhu LAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Aramchol; Fatty acid bile acid conjugate; Synthesis; Treating disordered lipid metabolism
- From: Chinese Pharmaceutical Journal 2013;48(11):920-924
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To optimize the process of synthesizing aramchol. METHODS: Using arachidic acid (eicosanoic acid) and cholic acid as the starting materials, 3β-arachidyl-amido-7α, 12α-dihydroxyl-5β-cholanic-24-acid, a fatty acid bile acid conjugate aramchol, was synthesized through a 9 step route in which the carboxyl group and hydroxyl groups of cholic acid has been orthogonally protected and regioselectively deprotected. RESULTS: The yield of the target product was 12.7%. CONCLUSION: With reproducibile reactions, less by-products, and mild, controllable and relatively safe conditions, the improved process is very suitable for lab-scale production.
