Effects of Huannao Yicong Fomula on learning, memory and anti-oxidative function of D-galactose combined with high fat diet induced cognitive impairment model rats
10.11669/cpj.2013.11.008
- Author:
Lin LIANG
1
Author Information
1. Xiyuan Hospital
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Cognitive impairment;
Huannao Yicong Fomula;
Morris water maze;
Oxidative stress
- From:
Chinese Pharmaceutical Journal
2013;48(11):867-871
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To produce a rat model of cognitive impairment by D-galactose combined with a high fat diet method, and observe the learning and memory function and the change of oxidative stress indexes of the model rats. Discuss the effects of Huannao Yicong Fomula(HNYCF) on learning, memory and oxidative stress of the model. METHODS: The cognitive impairment rat model was induced by hypodermic injection of D-galactose and combined with half fat diet. Morris water maze test was used to detect the learning and memory ability. The level of SOD, MDA, T-AOC, GSH-PX was tested. RESULTS: in model group, the learning and memory ability was severely impaired, hippocampal neurons were reduced, SOD, T-AOC, GSH-PX level significantly decreased, MDA level increased. The administration of HNYCF improved memory ability, improved SOD, T-AOC, GSH-PX levels, reduced MDA activity in serum and hippocampus tissues. CONCLUSION: D-Galactose combined with high fat diet can cause disorders of oxidative stress in rats, leading to cognitive impairment. HNYCF can significantly improve the antioxidant stress ability, improve learning, memory and spatial cognitive ability of rats.
