Preparation of drug-loaded polyvinyl alcohol-sodium alginate nanofiber by electrospinning
- Author:
Chen-Wen LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Accumulated release rate; Electrospun nanofiber; Polyvinyl alcohol; Sodium alginate
- From: Chinese Pharmaceutical Journal 2013;48(12):980-985
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To fabricate moxifloxacin hydrochloride-loaded polyvinyl alcohol (PVA)-sodium alginate (SA) nanofiber using the electrospinning technique and investigate the drug release in vitro. METHODS: Central composite design-response surface methodology was used to investigate the influences of various factors, i.e., PVA content, SA content, the ratio of PVA-SA, on the accumulated release rate of moxifloxacin hydrochloride from the nanofibers. The scaffolds were cross-linked by CaCl2 ethanol solution. Fiber morphology was characterized using optical microscope and scanning electron microscopy (SEM). Drug entrapment efficiency was determined, and drug release profiles were tested. RESULTS: Moxifloxacin hydrochloride entrapment efficiencies were well above 65%. Drug was released from the nanofibers as a linear function of the square root of time, suggesting accordance with Fickian kinetics. The relationship between the independent variables and the dependent variables was in accordance with quadratic model. CONCLUSION: The PVA-SA nanofiber presents good release characteristics, and has a good prospect as drug carrier.
