Systemic toxicity of (S)-(-)-pantoprazole sodium in rats following intravenous injection for 30 d
- Author:
Xiao-Li DAI
1
Author Information
- Publication Type:Journal Article
- Keywords: Caudal vein; Consecutive intravenous injection; Pantoprazole sodium; Rat; S-(-)-pantoprazole sodium; Systemic toxicity
- From: Chinese Pharmaceutical Journal 2013;48(13):1060-1064
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: The systemic toxicities of S-(-)-pantoprazole sodium in rats following intravenous injuction for 30 d were studied. METHODS: One hundred rats were divided randomly into 5 groups: vehicle control group, pantoprazole sodium control group and three S-(-)-pantoprazole sodium groups with different dosages, and received vehicle, pantoprazole sodium(80 mg·kg-1·d-1), S-(-)-pantoprazole sodium(80, 40 and 20 mg·kg-1·d-1) by i.v.via tail vein. Administrations were performed each day for consecutive 30 d. Haematological parameters, biochemical parameters, and histopathology analysis were determined at 30 d of treatments and 14 d after the withdrawal, respectively. RESULTS: The rats in the S-(-)-pantoprazole sodium group at 80 mg·kg-1·d-1 apperanced shortness of breath, unsteady gait, lying motionless and other symptoms. The levels of TC, Na+, Cl- in this group were significantly higher or lower than those in vehicle control group at 30 d(P<0.05), The change of these parameters regained to normal at 14 d after withdrawal. CONCLUSION: Intravenous administration of the S-(-)-pantoprazole sodium for 30 d at high dose could induce reversible damage to liver and electrolyte. The toxicity of S-(-)-pantoprazole sodium is similar with pantoprazole sodium at the same dosage.
