Research progress in chemoresistance mechanism of paclitaxel and the future direction

Author: Jing-Wei YU ¹
Author Information

1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)
Publication Type:Journal Article
Keywords: β-tubulin III; Chemoresistance; Microtubule-associated proteins Tau; Paclitaxel
From: Chinese Pharmaceutical Journal 2013;48(14):1147-1150
CountryChina
Language:Chinese
Abstract: OBJECTIVE: To review the chemoresistance mechanism of paclitaxel and the latest relevant researches. METHODS: Based on the newest research reports at home and abroad, the structure, antitumor mechanism and possible resistance mechanisms of paclitaxel were analyzed and summarized. RESULTS: Many influencing factors and mechanisms of paclitaxel resistance were summarized, among which, β-tubulin III and microtubule-associated proteins Tau were laid special stress on. CONCLUSION: Many factors and mechanisms are involved in the resistance of paclitaxel. In order to improve the specificity and accuracy, multiple possible factors and mechanisms should be considered, rather than one factor or one biomarker. Only in this way, can we achieve the individualized treatment of paclitaxel in clinic.