Advance on the research of cell-penetrating peptides
- Author:
Chun-Meng SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: Cell-penetrating peptide; Classification; Internalization mechanism; Structure property
- From: Chinese Pharmaceutical Journal 2013;48(14):1143-1147
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To review the progress on cell-penetrating peptides(CPPs). METHODS: Based on the original researches in recent years, the structure properties, classification, internalization mechanism, application and novel research orientation of CPPs were introduced in the present paper. RESULTS: Cell-penetrating peptides(CPPs) consisted of 30 or less amino acids. CPPs, generally categorized as amphipathic or cationic depending on their sequences, are increasingly drawing attention as a non-invasive delivery technology for macromolecules. Delivery of a diverse set of cargoes has been attempted using different types of CPPs in vitroand in vivo. Additionally, the relative lack of toxicity and cell specificity has enabled its widespread use in preclinical models. This paper reviewed the studies on the structure properties, classification, internalization mechanism, application and novel research orientation of CPPs. CONCLUSION: Although the internalization mechanism of CPPs will be studied deeply, CPPs, as a novel drug delivery tool, has promising application for the delivery of diverse drugs and cargoes.
