Application of humanized mice in drug metabolism and toxicity
- Author:
Zhi-Tao WU
1
Author Information
- Publication Type:Journal Article
- Keywords: CYP450; Drug metabolism; Humanized mice; Induction; Inhibition; Toxicity
- From: Chinese Pharmaceutical Journal 2013;48(14):1137-1142
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To discuss the application of humanized mice model in drug metabolism and toxicity. METHODS: By sorting foreign scientific literature, the history of the development of humanized mice model and its application in drug metabolizing enzymes and toxicity studies were reviewed and summarized to provide support for early drug development. RESULTS and CONCLUSION: The humanized mice model could reduce interspecies differences and has been increasingly used in drug metabolism and safety evaluation in foreign countries. Transgenic mice can be applied to studying the metabolism of drugs metabolized by certain enzyme. In the chimeric mice body, the disposal of drugs could be more systematic and comprehensive mirrored, predicting this model has enormous potential in drug discovery and development.
