Research progress of nanoemulsions' applications in improving the bioavailability of poor water-soluble drugs
- Author:
Peng-Fei YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Bioavailability; Nanoemulsion; Nanotechnology; Oral administration; Poorly soluble drug
- From: Chinese Pharmaceutical Journal 2013;48(15):1238-1244
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: Learning about the progress of the nanoemulsion drug carrier in the application of the insoluble medicament. METHODS: According to the recent literature and our groups work in this area, the nanoemulsion in improving the bioavailability of poorly soluble drugs has been discussed in many aspects, including its formulation mechanism, preparation methods, Pharmacokinetic, pharmacodynamics and modern application of the traditional Chinese medicine preparation in the recent research. RESULTS: Nanoemulsion carrier insoluble drugs could significantly improve oral absorption rate and bioavailability, enhance targeting effect and reduce the drugs toxicity. CONCLUSION: The select of the optimal scale of production based on the medicinal properties process allowed the nanoemulsion insoluble drugs to achieve a good therapeutic effect after oral administration.
