Preparation and verification of honokiol-hydroxypropyl-β-cyclodextrin inclusion complex
10.11669/cpj.2013.16.012
- Author:
Cai-Bing XU
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Honokiol;
Hydroxypropyl-β-cyclodextrin;
Inclusion complex
- From:
Chinese Pharmaceutical Journal
2013;48(16):1385-1388
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare and verify honokiol-hydroxypropyl-β-cyclodextrin inclusion complex (HK-HPCD). METHODS: HK-HPCD was prepared by the stirring method. The main factors affecting the inclusion rate were studied by single factor analysis and the optimum procedure for preparation was selected by central composite design. The inclusion complex was verified by differential scanning calorimetry (DSC) and infrared spectra. RESULTS: The optimum preparation process parameters were as follows: the molar ratio of honokiol to HP-β-CD was 1:5, the reaction temperature was 50°C and the reaction time was 3 h. CONCLUSION: Stable complex can be formed between honokiol and HP-B-CD, and the solubility of honokiol is increased by HP-B-CD significantly.
