Development of research on regulation mechanism of epigenetic modifications for drug metabolic enzymes
- Author:
Zi-Zhao YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Disease prevention; Drug metabolism enzyme; Epigenetic modification; Substrate metabolism
- From: Chinese Pharmaceutical Journal 2013;48(17):1425-1428
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To make a review of nowadays related dissertations about epigenetic modifications (DNA methylation, histone modifications, chromatin remodeling and the non-coding microRNA interruption, etc.) mediating the abnormal expression of drug metabolic enzymes and inactive metabolism of substances in organisms. METHODS: Researches on epigenetic modifications regulating the genes expression or activity change of drug metabolism enzymes were reviewed. RESULTS AND CONCLUSION: The research in this field can provide reference for determining biomarkers in clinical diagnosis and therapies of tumors.
