Synthesis of miriplatin, a novel platinum-based antitumor-drug
- Author:
Qing-Kun WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Antitumor drug; Chemical synthesis; Miriplatin
- From: Chinese Pharmaceutical Journal 2013;48(18):1594-1595
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To synthesize the platinum-based anti-tumor drug miriplatin. METHODS: Miriplatin was synthesized from K4PtCl4. K4PtCl4 was reacted with sodium nitrite to give the K4Pt(NO2)4 solution which reacted with(IR, 2R)-1,2-cyclohexane-diamine thus resulting in the key intermediate Pt(C6H14N2) (NO2)2. The key intermediate was subsequently reacted with hydrazine sulfate and sodium myristate in n-butanol to give the target compound. The structure of the target compound was identified by elemental analysis, ESI-MS, FT-IR, H-NMR, thermal analysis and specific optical rotation measurement. RESULTS: The structure of the synthesized compound was consistent with the title compound, and the yield was about 61%. CONCLUSION: This study provides a novel synthesis process for miriplatin.
