Protective effects of Acanthus ilicifolius alkaloids a and its derivatives on immune hepatic fibrosis in rats
- Author:
Li-Juan ZHOU
1
Author Information
- Publication Type:Journal Article
- Keywords: Acanthus ilicifolius alkaloids A; Immune hepatic fibrosis; Porcine serum
- From: Chinese Pharmaceutical Journal 2013;48(20):1744-1747
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To research the protective effects of Acanthus ilicifolius alkaloids A and its two derivatives in the rats with immune hepatic fibrosis. METHODS: Immune hepatic fibrosis model was established by intraperitoneal administration porcine serum. SD rats were treated intragastric administration with [4-hydroxy-2 (3H)-benzoxazolone, HBOA], [4-acetoxy-2 (3H)-benzox-azolone, AcO-BOA], (3-acetyl-4-acetoxy-2-benzoxazolone, TC-3). The activities of ALT, AST in serum and the levels of HA and LN in serum were measured. RESULTS: Compared with the normal control group, the activities of ALT, AST and the levels of HA and LN in the model group were significantly increased. Compared with the model group, animals treated with the HBOA, AcO-BOA or TC-3 could decrease the activities of ALT and AST and the levels of HA and LN markedly. Histopathological results showed that treatment groups could relieve the porcine serum-induced liver damage. CONCLUSION: HBOA and its derivatives have protective effect on the rats with immune-mediated hepatic fibrosis.
