Formulation optimization of pressure indicator for prosthodontics
- Author:
Li-Ting LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Orthogonal test; Pressure indicator; Prosthodontics; Stability
- From: Chinese Pharmaceutical Journal 2013;48(22):1928-1932
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To optimize the formulation of pressure indicator based on spreadability, nonadhesion to oral mucosa, and difficulty of removal. METHODS: The formulation components were screened by colligation score, the optimal formulation was designed by orthogonal test, and the heat-resistance, cold-resistance, and stability of the optimal formulation were evaluated. RESULTS: The optimized pressure indicator using lanolin as the main ingredient had good color coverage and suitable viscosity which allowed easy coating of the internal surfaces of dentures and no adherence to the oral mucosa at the same time. And it could be removed easily. The results of orthogonal test showed that the ratio of lanolin and water was the main factor affecting the performance of the pressure indicator. The optimized formulation was stable. CONCLUSION: The optimized pressure indicator has good performance and good clinical response. The preparation process is simple. The property of optimized pressure indicator is stable and the quality can be controlled.
