Preparation of inclusion complex of piperine with β-cyclodextrin and exploration of the properties of inclusion complex system
10.11669/cpj.2013.21.016
- Author:
Ming GUO
1
Author Information
1. School of Engineering
- Publication Type:Journal Article
- Keywords:
β-cyclodextrin;
Gaussian calculation;
Inclusion complex;
Piperine
- From:
Chinese Pharmaceutical Journal
2013;48(21):1841-1846
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare a novel inclusion complex of the piperine with β-cyclodextrin (β-CD) by the saturated solution method and characterize the inclusion mechanism by fluorescence spectroscopy and ultraviolet spectrometry. METHODS: The dissolution properties and the balance properties of the inclusion complex were analyzed by ultraviolet spectrum and the Gaussian method was used to calculate the inclusion complex's configuration and thermodynamic parameters. The interaction performance of β-cyclodextrin-piperine supermolecular system was explored by spectroscopic experiment combined with theoretical calculation. RESULTS: The results showed that the spectral method better characterize the piperine-β-cyclodextrin. The stability and solubility of piperine was significantly improved after it was included with β-cyclodextrin. Gaussian calculation successfully obtains the preferred molecular configuration and the total energy change effect of inclusion system, the thermodynamic parameters of the piperine-β-cyclodextrin were also be obtained and showed that the inclusion process of the inclusion complex is a spontaneous binding reaction, which was further confirmed by spectral experiments. CONCLUSION: The stability and solubility of piperine can be significantly improved after β-cyclodextrin including, the results can provide certain reference for the study of inclusion complex supermolecular system.
