The cross-section study on warfarin anticoagulation effects with amiodarone's combination in different CYP2C9 and VKORC1 status
- Author:
Zhi-Hong WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Amiodarone; CYP2C9; Drug interaction; Gene analysis; VKORC1; Warfarin
- From: Chinese Pharmaceutical Journal 2013;48(24):2150-2153
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To analyse the effect of amiodarone on the warfarin anticoagulation effects in different CYP2C9 and VORCORC1 status. METHODS: From January 2010 to November 2012, patients on warfarin therapy with or without amiodarone medication were included whose blood samples were collected and tested in VKORC1 and CYP2C9 genotypes and whose clinical data were collected. The clinical characterics, warfarin medication related data were compared between the groups with and without amiodarone therapy and the genotype status were used in the following subgroup analysis. RESULTS: There are no statistically difference of warfarin dosage or INR(international ratio of PT) value between the groups with and without amiodarone medication and no statistically difference in the following analysis of genotype subgroup. CONCLUSION: The patients on short-duration usage of amiodarone has no obviously effect on warfarin stable dosage and INR value during stable dosage.
