Advance on population pharmacokinetic models of vancomycin
- Author:
Xiao-Rong HE
1
Author Information
- Publication Type:Journal Article
- Keywords: Model; Population pharmacokinetics; Vancomycin
- From: Chinese Pharmaceutical Journal 2013;48(24):2075-2080
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To review population pharmacokinetics of vancomycin in recent years, and to provide methods for rational application vancomycin in clinical practice. METHODS: According to literatures, population pharmacokinetic models of vancomycin were reviewed. RESULTS AND CONCLUSION: Population pharmacokinetic models were better reasonable to predict accurate pharmacokinetic parameters of individuals, especial for the subpopulations, such as children, severe obesity, cancer and so on. They could help clinicians to select proper dosing of vancomycin to individualize the therapy in different patient populations. This way could reduce side effects and resistances of vancomycin through individualized administration.
