The application of reduction-sensitive polymeric micelles in tumor targeting drug delivery
- Author:
Xing-Xing CHUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Disulfide bond; Drug delivery; Polymeric micelle; Reduction-sensitive; Tumor targeting
- From: Chinese Pharmaceutical Journal 2013;48(24):2069-2075
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To introduce the application of reduction-sensitive polymeric micelles in the field of tumor targeting drug delivery. METHODS: In the past decades, tumor targeted drug delivery systems have become important research area because they promise to resolve several key therapeutical issues including low treatment efficacy and significant side effects. On the basis of published literatures, the recent developments in reduction-sensitive polymeric micelles used for tumor targeting drug delivery were reviewed, with an emphasis on their structure characteristics as well as their biomedical applications from the cellular level and animal level, respectively. RESULTS AND CONCLUSION: As a novel intelligent drug delivery system, reduction-sensitive polymeric micelles can effectively control drug release with low side effects and high therapeutic effects both in vitro and in vivo. It has great potential in tumor targeting drug delivery.
