Chemical relationship study of aconitum soongaricum stapf based on HPLC fingerprint

Author: Fei-Cui ZHAO ¹
Author Information

1. Affiliated Traditional Chinese Medical Hospital, Xinjiang Medical University
Publication Type:Journal Article
Keywords: Aconitum soongaricum Stapf.; Chemical relationship; HPLC fingerprint; Similarity analysis
From: Chinese Pharmaceutical Journal 2014;49(24):2159-2164
CountryChina
Language:Chinese
Abstract: OBJECTIVE: To compare the HPLC fingerprints Aconitum soongaricum Stapf. with Aconitum carmichaelii Debx., Aconitum kusnezoffii Reichb., and another common radix aconite plant in Xinjiang, Aconitum leucostomum Worosch., and analyze the degree similarity between different fingerprints. METHODS: The HPLC fingerprint Aconitum soongaricum Stapf was established, and similarity analysis, cluster analysis and principal component analysis were carried out for the common patterns, Aconitum soongaricum Stapf and Aconitum carmichaelii Debx., Aconitum kusnezoffii Reichb., and Aconitum leucostomum Worosch. via the ChemPattem chemical fingerprint analysis system software solutions. RESULTS: The analysis showed that the similarities the mutual model reference fingerprints were higher between Aconitum soongaricum Stapf and Aconitum kusnezoffii Reichb. and between Aconitum leucostomum Worosch. and Aconitum carmichaelii Debx. CONCLUSION: It is preliminarily determined that Aconitum soongaricum Stapf in Xinjiang had higher similarity with the legal standard Aconitum kusnezoffii Reichb., which deserves further research and development.