Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome.
10.1016/j.krcp.2014.08.002
- Author:
Eun Chae LEE
1
;
Geun A KIM
;
Ja Wook KOO
Author Information
1. Department of Pediatrics, Sanggye Paik Hospital, Inje University, College of Medicine, Seoul, Korea. koojw9@paik.ac.kr
- Publication Type:Case Report
- Keywords:
Deflazacort;
Intravenous immunoglobulin-G;
Nephrotic syndrome;
Toxic epidermal necrolysis
- MeSH:
Adolescent;
Child, Preschool;
Enalapril;
Epidermis;
Humans;
Intensive Care Units;
Lower Extremity;
Male;
Necrosis;
Nephrotic Syndrome*;
Recurrence;
Skin;
Stevens-Johnson Syndrome*
- From:Kidney Research and Clinical Practice
2014;33(4):222-225
- CountryRepublic of Korea
- Language:English
-
Abstract:
Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (>50%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement after intravenous immunoglobulin-G therapy. Owing to the rapid, fatal course of TEN, clinicians need to be aware of the adverse effects of this drug when treating cases of NS.