Preparation and in vitro mucosal penetration evaluation of ph-sensitive thiolated chitosan nanoparticles for low molecular weight heparin delivery
- Author:
Chuan SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: Low molecular weight heparin; Mucosal penetration; Nanoparticle; PH-sensitive; Thiolated chitosan
- From: Chinese Pharmaceutical Journal 2014;49(16):1414-1419
- CountryChina
- Language:Chinese
- Abstract: METHODS: The pH-sensitive thiolated chitosan nanoparticles were prepared by ionic cross-linking reaction and characterized for the shape, particle size, Zeta potential, drug entrapment efficiency and loading capacity. In vitro release of low molecular weight heparin from the prepared nanoparticles was evaluated in 0.1 mol•L-1 HCl solution and phosphate buffered saline (PBS) at pH 6.8 using the dialysis method. The intestinal permeability was estimated utilizing Franz diffusion cell system.
