Risk Factors Influencing Decline of Residual Renal Function in Patients on Continuous Ambulatory Peritoneal Dialysis.
- Author:
Gun Hyun KIM
1
;
Seung Hyea HYUN
;
Hye Jin SEO
;
Ji Young CHOI
;
Ji Hyung CHO
;
Chan Duck KIM
;
Sun Hee PARK
;
Yong Lim KIM
Author Information
1. Division of Nephrology, Department of Internal Medicine, Kyungpook National University, School of Medicine and Clinical Research Center for ESRD, Daegu, Korea. sh-park@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Continuous ambulatory peritoneal dialysis;
Proteinuria;
Left ventricular hypertrophy
- MeSH:
Body Surface Area;
Creatinine;
Hematocrit;
Humans;
Hypertrophy, Left Ventricular;
Nitrogen;
Peritoneal Dialysis;
Peritoneal Dialysis, Continuous Ambulatory;
Proteinuria;
Renal Insufficiency, Chronic;
Retrospective Studies;
Risk Factors;
Urea;
Urine Specimen Collection
- From:Korean Journal of Nephrology
2010;29(6):752-760
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Preservation of residual renal function (RRF) after initiation of peritoneal dialysis (PD) is beneficial for patient survival. It is unclear that same risk factors of pre-dialysis chronic kidney disease (CKD) patients affect RRF in PD patients. This study was aimed to evaluate factors affecting RRF after commencement of PD. METHODS: Data from 80 patients commencing CAPD at Kyungpook National University Hospital between January 2001 and December 2008 were retrospectively collected. After PD commencement, biochemical and clinical data at baseline (1 month), 6, and 12 month were obtained. RRF was calculated as the average of creatinine clearance and urea nitrogen clearance from 24-hour urine collection and normalized with body surface area and mean RRF decline rate was calculated by dividing RRF difference between baseline to 12 month by period. RESULTS: Mean RRF decline rate (mL/min/1.73m2/month) was negatively correlated with left ventricular posterior wall thickness (LVPWT) (R2=0.097, p=0.023) and proteinuria (R2=0.126, p=0.003), whereas positively correlated with hematocrit (R2=0.076, p=0.013) at baseline. CONCLUSION: Decline of RRF during a year after commencement of PD was associated with baseline proteinuria and LVPWT.
