Preparation and in vitro properties of montmorillonite/matrine nanocomposite
10.11669/cpj.2014.02.012
- Author:
Cai-Yun ZHANG
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Matrine;
Montmorillonite;
Sustained release carrier;
Urea
- From:
Chinese Pharmaceutical Journal
2014;49(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To use montmorillonite as the carrier of matrine. METHODS: Urea was used to insert into the montmorillonite interlayer by solid-phase grinding method. After this process, the matrine was loaded by the solution blending to obtain montmorillonite/matrine nanocomposite. RESULTS: XRD and FT-IR showed that the urea was intercalated into the montmorillonite layers, and the interlayer spacing of montmorillonite was enlarged from ca. 1.2 to 1.7 nm. With the help of the urea, the matrine was successfully loaded into the montmorillonite layers, at the same time the interlayer distance of the montmorillonite was further increased to 1.86 nm. In vitro release experiments displayed that the release of montmorillonite/matrine composite accorded with the Higuchi e-quation, indicating that the montmorillonite could sustain the release of matrine. MTT measurement showed that the montmorillonite/matrine nanocomposite has significant cytotoxicity on human gastric cancer cells (SGC7901). CONCLUSION: This research suggests the feasibility of montmorillonite as the sustained release carrier for the matrine and other alkaloids drug, and provides the evidence for montmorillonite in the pharmaceutical field as drug carriers.
