MPO-ANCA Associated Rapidly Progressive Glomerulonephritis in A Patient with Mixed Connective Tissue Disease.
- Author:
Hyun Seok HONG
1
;
Ji Hoon PARK
;
Ju Hyun LEE
;
Joo Hark YI
;
Sang Woong HAN
;
Moon Hyang PARK
;
Ho Jung KIM
Author Information
1. Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea. cardion@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
ANCA;
Glomerulonephritis;
Mixed connective tissue disease
- MeSH:
Antibodies, Antineutrophil Cytoplasmic;
Arthralgia;
Arthritis, Rheumatoid;
Autoimmune Diseases;
Biopsy;
Collagen;
Female;
Glomerulonephritis;
Humans;
Immunologic Tests;
Kidney;
Middle Aged;
Mixed Connective Tissue Disease;
Scleroderma, Systemic;
Uremia;
Vascular Diseases
- From:Korean Journal of Nephrology
2010;29(6):776-781
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mixed connective tissue disease (MCTD) has the clinical feature of other collagen vascular diseases. According to several reports recently published, MCTD sometimes involved kidney as benign course. ANCA associated glomerulonephritis occurred in systemic autoimmune disease such as systemic sclerosis or rheumatoid arthritis, not in MCTD. In this case, as we experienced that MPO-ANCA associated glomerulonephritis arose and proceeded to rapid progressive glomerulonephritis (RPGN) in women with MCTD, we report it with review of reference. A 60-year-old woman was admitted with uremia and joint pain. In physical finding and serum test, she was diagnosed with MCTD according to Khan`s criteria. Also MPO antibody and ANCA were noted in specific immunological test and the histologic findings showed crescentic glomerulonephritis. So we diagnosed RPGN induced by MPO-ANCA associated glomerulonephritis. She was treated with immunosuppressive treatment and uremia was improved. RPGN induced by MPO-ANCA associated glomerulonephritis should be ruled out by prompt renal biopsy and require proper treatment.
