Research progress in the content assay methods of sulfate polysaccharide drugs
- Author:
Yi-Ting XUE
1
Author Information
- Publication Type:Journal Article
- Keywords: Chondroitin sulfate; Content assay; Heparin; Propylene glycol alginate sodium sulfate; Propylene glycol man-nuronate sulfate; Sulfate polysaccharide
- From: Chinese Pharmaceutical Journal 2014;49(4):271-274
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To review the progress in the content assay methods of sulfate polysaccharide drugs. METHODS: By nonsuiting the literature at home and abroad in recent years, the content assay methods of sulfate polysaccharide drugs, including direct staining method, acid-degradation color-development method, photometric titration, liquid chromatography and biopotency, are introduced and compared. RESULTS AND CONCLUSION: The specificity, precision and accuracy, feasibility of practical operation and the instrument cost of the five methods are different. But high performance liquid chromatography method with good specificity, high sensitivity, and accuracy can give more accurate result of the drug content. It is more widely applied in the determination of drug content, so it will be the main method of content assay in the future.
