Materials with lysosomal escape function and its mechanism
- Author:
Mi-Na YAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Lysosomal escape; Membrane fusion; Proton sponge effect
- From: Chinese Pharmaceutical Journal 2014;49(4):265-270
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To review the progress on materials with lysosomal escape function. METHODS: Based on the original researches in recent years, the structure properties and escape mechanism of materials with lysosomal escape function were introduced in the present paper. RESULTS: The materials which can help the drug/gene to get out of the lysosomes were summarized and classified into two groups in the accordance with their escape mechanism: breaking the lysosomes by raising the osmotic pressure or destabilizing the membrane structure of lysosomes. CONCLUSION: The materials with lysosomal escape function, as a novel drug delivery tool, has promising application for the delivery of drug/gene and need to be studied deeply before the materials get widely applied.
