Preparation and drug release performance of ph sensitive hot-melt pressure sensitive adhesives
- Author:
Xiao TONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Drug release; EPO; SIS; Transdermal; Weakly acidic condition
- From: Chinese Pharmaceutical Journal 2014;49(5):377-383
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To Prepare amphiphilic hot-melt pressure sensitive adhesives (HMPSAs) and investigate the relationship among components, adhesion performance, drug release behavior of pH and transdermal permeation ability. METHODS: Based on the blend of styrene-isoprene-styrene (SIS) thermoplastic elastomer and acrylic resin Eudragit® EPO, following the addition of an appropriate amount of polyethylene glycol (PEG), mineral oil and C5 resin, the amphiphilic HMPSAs were prepared. The compatibility and micromorphology of SIS/EPO blends (SEBs) were analyzed with differential scanning calorimetry (DSC), atomic force microscopy (AFM) and scanning electron microscopy (SEM). The adhesive performance of HMPSAs was measured as 180° peeling strength and holding power. H-nuclear magnetic resonance spectrometer (H-NMR) was used to investigate the interaction between drugs and HMPSAs. The drug release behavior of arbutin and other five drugs were investigated, and the in vitro transdermal permeation was examined on mice's skin to compare the transdermal permeation ability of sinomenine hydrochloride and paeoniflorin in different HMPSAs. RESULTS: When the mass ratio of SIS to EPO was 1:2, bicontinuous structure was formed. The HMPSAs could maintain good adhesion performance, achieve continual release of both hydrophilic and lipophilic drugs and exhibit good transdermal permeation ability for hydrophilic drugs as well. Due to the protonation of EPO, the amphiphilic HMPSAs exhibited higher release rate and transdermal permeation ability in weakly acidic condition. CONCLUSION: The modified HMPSAs show good adhesive performance and pH sensitivity, so they are suitable for transdermal drug delivery system (TDDS).
