Progress in the chemical synthesis of artemisinin
- Author:
Yan-Hui FU
1
Author Information
- Publication Type:Journal Article
- Keywords: Artemisinin; Research progress; Semi-synthesis; Total synthesis
- From: Chinese Pharmaceutical Journal 2014;49(10):795-805
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To introduce the research progress in total-and semi-synthesis of artemisinin. METHODS: The review was based on representative literatures, and the data was summarized and analyzed. RESULTS AND CONCLUSION: Artemisinin is one of the most effective anti-malarial medicines. Since its discovery, artemisinin chemical synthesis has become a hot research topic. Nine total-synthesis methods andfive semi-synthesis methods were summarized, for which the overall yields were up to 10% and 60% respectively. Efficient synthesis of artemisinin in large scale by industry would be realized in the near future, and it will benefit hundred millions of patients.
