Antitumor effect of 16-dehydropregnenoione liposomes
- Author:
Zheng QIN
1
Author Information
- Publication Type:Journal Article
- Keywords: 16-dehydropregnenolone; Antitumor effect; HeLa; Liposomes
- From: Chinese Pharmaceutical Journal 2015;50(14):1202-1207
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE: To investigate the antitumor effect of 16-dehydropregnenolone (16-DHP) liposomes. METHODS: Twelve kinds of tumor cells were used to determine the cytotoxic effect of 16-DHP liposome by MTT assay. The established tumor xenograft in nude mouse model was used to evaluate anti-tumor effect of 16-DHP liposomes after tail vein injection. RESULTS: IC
50 value of 16-DHP liposomes to the human hepatoma cell HepG2, human oral carcinoma KB cell, human breast cancer T47D, human gastric cancer cell SGC7901, human fibrosarcoma cell HT1080, human ovarian cancer cell SKOV3, human prostate cancer cell PC3, human prostrate cancer cell DU145, human lung cancer cell A549, human rhabdomyosarcoma A204 cell and human cervical carcinoma cell HeLa were 44.69, 9.17, 26.22, 19.58, 28.01, 37.18, 24.58, 21.38, 54.69, 4.18 and 8.96 μg · mL-1, respectively. The relative tumor increment rate and inhibition rates of tumor weight were 93.7%, 60.52%, 37.84% and 23.05%, 48.84%, 69.70% respectively after treated with 16-DHP liposomes (7.5, 15 and 30 mg · kg-1 · d-1, 28 d). CONCLUSION: 16-DHP liposomes possess in vitro and in vivo anti-tumor activities.
