Effect of borneol on absorption of chlorogenic acid by two absorption models and its correlation of these absorption models
10.11669/cpj.2015.09.013
- Author:
Jing REN
1
Author Information
1. Chengdu University
- Publication Type:Journal Article
- Keywords:
Borneol;
Chlorogenic acid;
Correlation;
In situ perfusion model;
Relative bioavailability
- From:
Chinese Pharmaceutical Journal
2015;50(9):793-796
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the enhancing effect of borneol on the absorption of chlorogenic acid (CGA) with two different biological models and to evaluate the correlation of these two models. METHODS: The in situ rat perfusion model was used to investigate the enhancing effect of borneol on the absorption of CGA. The in vivo pharmacokinetics study was carried out to evaluate the correlation of the two-compartment open model. RESULTS: With the in situ rat perfusion model, the absorption rate constant (Ka) of CGA was 0.083 4 h-1, which was up to 1.58-fold higher by borneol. The results of in vivo pharmacokinetics study in rats suggested that 0.04% borneol could increase the relative bioavailability by 116.02% and maximum plasma concentration increased slightly. The consistent result of these two different absorption models was provided (r=0.941). CONCLUSION: Borneol could promote the oral absorption of CGA.
