Discovery of nortadalafil in health foods
- Author:
Zhao-Hui HUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Health food; Nortadalafil; Tadalafil analogue
- From: Chinese Pharmaceutical Journal 2015;50(4):371-374
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To identify an unknown tadalafil analogue illegally adulterated in health foods. METHODS: An unknown tadalafil analogue was observed in a routine screening for compounds illegally adulterated in heath foods by HPLC-DAD. The compound of interest was isolated by silica gel thin layer chromatography. Its molecular weight and structural fragments were obtained by UPLC-MS/MS, and its 1H-NMR spectum was also obtained using nuclear magnetic resonance. Its structure is elucidated by analysis of these data in combination of the literature. RESULTS: A new tadalafil analogue, nortadalafil, was detected in health foods. CONCLUSION: This is the first time to disclose that nortadalafil was illegally adulterated in health foods. It's necessary to supplement the current inspection standard, which lists 11 target compounds but not including nortadalafil, to punish the illegal producers in time.
