Moisture sorption properties research of chemical reference substances based on dynamic vapor sorption analysis technology
- Author:
Jing XIONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Adsorption-desorption isotherm; Aspirin; Bosentan; Disodium etidronate; Dynamic vapor sorption; Hygroscopicity; Moisture sorption dynamics; Sodium aminosalicylate; Valaciclovir hydrochloride
- From: Chinese Pharmaceutical Journal 2015;50(6):532-535
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the moisture sorption properties of chemical reference substances (CRSs) by using dynamic vapor sorption (DVS) analysis technology in order to establish the distribution conditions, packaging materials, and usages of national chemical reference substances. METHODS: DVS analysis was adopted to acquire the moisture sorption dynamic profiles of five chemical reference substances of different moisture sorption types to evaluate their moisture sorption trend and capacities under different humidities. RESULTS: According to moisture sorption dynamics, we can found the hygroscopicity of disodium etidronate, sodium aminosalicylate, valaciclovir hydrochloride, aspirin and bosentan, and we have given advices about how to use these CRSs and what kind of bottles they should be packed in. CONCLUSION: DVS analysis can be used to record moisture sorption data in real time and visually observe water-CRS interactions under different humidities, which is an important technology for guiding the establishment and distribution of CRSs.
