Chemical constituents from swertia cincta burk. and their antagonistic effects on benign prostatic hyperplasia
- Author:
Shang-Xiu LI
1
Author Information
- Publication Type:Journal Article
- Keywords: 6'-O-β-D-glucopyranosylgentiopicroside; Benign prostatic hyperplasia; Swertia cincta Burk.; Swertiamarin
- From: Chinese Pharmaceutical Journal 2015;50(6):502-506
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the chemical constituents extracted from the whole plants of Swertia cincta Burk. and their antagonistic effects on benign prostatic hyperplasia (BPH). METHODS: The compounds were isolated by various chromatographic methods including silica gel, reverse silica gel, RP-HPLC, Sephadex LH-20, preparative TLC, and so on. Their structures were i-dentified by extensive analysis of the spectroscopic data. Experimental prostatic hyperplasia was produced in male Sprague-Dawley (SD) rats by testosterone injection for 28d, and then the prostate index(PI) was measured. RESULTS: Eleven compounds were isolated from the whole plants of Swertia cincta Burk. and identified as swertiamarin(1), (R)-(-)-gentiopicroside(2), sweroside(3), 6'-O-β-D-glucopyranosylsweroside(4), 6'-O-β-Z)-glucopyranosylgentiopicroside(5), loganic acid(6), oleanolic acid(7), 2α, 3β-dihydroxyolean-12-en-28-oicacid-28-O-β-D-glucopyranoside (8), β-daucosterol (9), 4-hydroxyl-3, 5-dimethoxyl-6-O-β-D-glu-cosebenzene(10), and isoorientin (11). Swertiamarin significantly decreased PI in SD rats. CONCLUSION: Compounds 5 and 8 were isolated irom the plants of Swertia cincta for the first time. Compound 1 has favorable effect for inhibiting prostatic hyperplasia in SD rats.
