Advances of the interaction between valproic acid and carbapenem antibiotics
- Author:
Xiao-Dong LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Carbapenem antibiotics; Drug interaction; Valproic acid
- From: Chinese Pharmaceutical Journal 2015;50(3):201-204
- CountryChina
- Language:Chinese
- Abstract: To critically evaluate the mechanisms of the interaction between valproic acid and carbapenem antibiotics. Research about the interaction between valproic acid and carbapenem antibiotics related case reports those were indexed from the Pubmed database. Studies to explain the decrease were carried out using rats and monkeys by the following mechanism; absorption, distribution, metabolism, and excretion of valproic acid. Carbapenem antibiotics induced a decrease of plasma concentration of valproic acid in epileptic patients during valproic acid therapy, resulting in the recurrence of epileptic seizures. Therefore, therapy with valproic acid and carbapenem antibibiotics should be avoided.
