Research development of prodrugs triggered by colon bacteria-releasing enzymes on colon-targeted treatment
- Author:
Jian-Di LIANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Colon-targeted; Prodrug; Triggered by colon bacteria-releasing enzyme
- From: Chinese Pharmaceutical Journal 2015;50(1):1-6
- CountryChina
- Language:Chinese
- Abstract: By researching the relevant papers at home and abroad, the principles of preparation, drug release mechanism, existing problems and so on were analysed and summarized on prodrugs triggered by colon bacteria-releasing enzymes (PTCBE). Compared with ordinary drugs, PTCBE was degraded by colon bacteria-releasing enzymes on colon-targeted treatment. PTCBE have the drug release characters of specificity, accuracy and so on for the colon-targeted treatment and can reduce the adverse drug reactions. Thus PTCBE have the good prospects of applications.
