Preparation of Lutein Thermosensitive in situ gels for ophthalmic use and the in vitro release
- Author:
Tian-Ye ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Central composite design-response surface methodology; Lutein; Membrane-less dissolution; Thermosensitive in situ gels
- From: Chinese Pharmaceutical Journal 2015;50(21):1880-1884
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To optimize the formulation of the lutein thermosensitive in situ gels by using central composite design-response surface methodology, and study the drug release in vitro. METHODS: Gelation temperature was served as the indicator. The influences of the amounts of Poloxamer 407 and Poloxamer 188 on the gelation temperature were investigated. Central composite design-response surface method was used to optimize the prescription. The drug release profile of the preparation was investigated with a membrane-less dissolution model. RESULTS: The amounts of Poloxamer 407 and Poloxamer 188 had quantitative relationships with the gelation temperature. The optimum prescription was as follows: the mass concentration of P407 was 0.21 g · mL-1, and the mass concentration of P188 was 0.03 g · mL-1. The dissolution and drug release of the gels followed zero-order kinetics equation. CONCLUSION: Central composite design-response surface methodology can be applied to optimize the formulation of the lutein thermosensitive in situ gels.
