Preparation and in vitro evaluation of ciprofloxacin hydrochloride gastro-retentive tablets
- Author:
Ru-Yi WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Agent; Ciprofloxacin hydrochloride; Dissolution; Gastro-retentive tablet; Hydrophilic polymer; Initial floating time
- From: Chinese Pharmaceutical Journal 2015;50(24):2135-2138
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the effect of polymers, including hydrophilic polymers and swelling aids, on floatability and dissolution of ciprofloxacin hydrochloride gastro-retentive tablets. METHODS: Hydroxypropyl methyl cellulose (HPMC), hydroxyethylcellulose (HEC) and hydroxypropylcellulose (HPC) were used as hydrophilic swelling excipients, and disintegrants crospovidone (PVPP XL and PVPP XL-10) or croscarmellose sodium (CCS) were used as swelling agents to facilitate the swelling/floating and drug release. Initial floating time and floating duration were tested to evaluate buoyance, and drug dissolution was tested to evaluate the controlled release. RESULTS: Using HPMC K250 and PVPP XL as excipients for ciprofloxacin hydrochloride gastro-retentive tablets could obtain products with rapid onset of floating, long floating durion and desirable drug release. CONCLUSION: Variety and amount of polymers have dramatic effects on buoyance and drug release of gastro-retentive tablets. HPMC K250 and PVPP XL are suitable excipients for ciprofloxacin hydrochloride gastro-retentive tablets.
