Role and research progress of TRPV4 in the pathogenesis of fibrosis diseases
- Author:
Shi-Feng ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Extracellular matrix (ECM); Fibrosis; TGF-β; Transient receptor potential; Transient receptor potential vanilloid 4
- From: Chinese Pharmaceutical Journal 2015;50(24):2095-2098
- CountryChina
- Language:Chinese
- Abstract: To analyze recent studies on the role of transient receptor potential vanilloid 4 (TRPV4) in fibrosis diseases and related mechanism. TRPV4 is a class of non-selective cation channel protein, which involved in intracellular divalent cations, mainly regulate Ca2+ homestasis and participate in the development of multiple organ fibrosis broadly. TRPV4 plays an important role in the prevention and treatment of fibrosis diseases. But for its complex mechanism of action, further research needs to be studied.
