Chemical constituents from Bletilla striata and their anti-tumor activities
- Author:
Ai-Jing SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: 2-hydroxysuccinic acid; 3β-hydroxyoleane-12-en-28-oic acid 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside; 4-hydroxybenzylamine; Anti-tumor; Bletilla striata; Cell cycle arrest
- From: Chinese Pharmaceutical Journal 2016;51(2):101-104
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the chemical constituents from Bletilla striata (Thunb.) Reichb.f and study their antitumor activities and effect on progression of cell cycle. METHODS: The compounds were isolated by various chromatographic methods including silica gel, ODS, Sephadex LH-20, and so on. Their structures were identified by extensive analysis of spectroscopic data. The antiproliferative effects of the compounds were evaluated using MTT test, and compound 1 was tested for the effect on the cell cycle of A549 cells. RESULTS: Five compounds were isolated from Bletilla striata and identified as 3β-hydroxyoleane-12-en-28-oic acid 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside(1), 2-hydroxysuccinic acid(2), 4-hydroxybenzylamine(3), palmitic acid(4), and 4-hydroxybenzoic acid(5). Compound 1 showed antiproliferative activity against the cancer cells and could induce G0/G1 phase arrest effectively after 24 h treatment. CONCLUSION: Compounds 1-4 are isolated from Bletilla striata for the first time. Compound 1 shows potent inhibitory effect and might produce their action through inducing cell cycle arrest.
