Advances in research of small molecule tyrosine kinase inhibitors for targeted cancer therapy
- Author:
Yan-Ning SONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Cancer; Small molecular inhibitor; Target; Tyrosine kinase inhibitor
- From: Chinese Pharmaceutical Journal 2016;51(3):165-171
- CountryChina
- Language:Chinese
- Abstract: To review the research progress of small molecule tyrosine kinase inhibitors (TKIs). Literatures on tyrosine kinase inhibitors which have already been successfully marketed or are in development were sorted and summarized according to the targets and related cancers. Through binding to catalytic domain of intracellular tyrosine kinase, small molecule TKIs inhibit the catalytic activity specifically and block cell proliferation signals, and some of them have already been used in cancer therapy or are in different stages of clinical development, showing good prospects.
