Preparation of Eudragit-chitosan bilayer colon-specific multi-dosage mini tablets
- Author:
Yun-Jie DANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Bilayer coated mini tablet; Chitosan; Enzyme triggered colon-specific mini tablet; Eugragit; Indomethacin
- From: Chinese Pharmaceutical Journal 2016;51(4):302-307
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To develop colon-targeting multi-dosage oral delivery system (mini tablet) using chitosan as the material for treatment of colon cancer. METHODS: Indomethacin (IN) was chosen as a model drug. Firstly, IN solid dispersion was prepared, then Eudragit-chitosan bilayer coated colon targeting mini tablets were prepared by direct compression method and coating technology. The release profiles of the targeting mini tablets in different release media were studied. Small animal in vivo fluorescence imaging investigation was used to sudy the transport and absorption in rats. Beagle dogs were used as animal model to study the pharmacokinetics and bioavailability of the mini tablets. RESULTS: The Eugragit-chitosan bilayer coated mini tablets maintained complete form when passing through the stomach and small intestine of rats, and targeted to the colon. The pharmacokinetic data in Beagle dogs showed that the mini tablets had delayed release and preserved steady absorption. CONCLUSION: The prepared Eudragit-chitosan bilayer coated multi dosage oral colon mini tablets showed good colon targeting effect and sustained release, which can provide important reference for the treatment of colon diseases.
