Role of TGF-p in idiopathic pulmonary fibrosis
- Author:
Cun-Gang ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Epithelial-to-mesenchymal transition; Extracellular matrix; Idiopathic pulmonary fibrosis; Transforming growth factor-β
- From: Chinese Pharmaceutical Journal 2016;51(5):341-345
- CountryChina
- Language:Chinese
- Abstract: Idiopathic pulmonary fibrosis (IPF) is a typical chronic, progressive fibrosing interstitial pneumonia, which is clinical characterized by progressive worsening of dyspnea and lung function with a poor prognosis. Since the pathogenesis is not clear, there is no efficiency cure for IPF until now. It is discovered that transforming growth factor-β (TGF-β), a "master switch" in the formation and development of IPF, plays an important role in the regulation of alveolar epithelial cells apoptosis, and the promotion of epithelial to mesenchymal transition and extracellular matrix synthesis. In this paper, the latest impacts of TGF-β on IPF are reviewed, which may provide the clues and evidence for the development of anti pulmonary fibrotic drugs.
